That's odd because the new iOS got rid of the error 53 code

Stop using the cheapest screens you can find. Use screens that have cold pressed frames.

I had this issue before it's the aftermarket parts but there is a solution that I do that really helps. Get a food saver vacuum sealer from Walmart. Put some crazy glue around the edges inside the new housing just a little you don't want it to run pop the screen in but don't screw it in. Put the phone in a vacuum sealed bag and let it sit for about 5 minutes. That will give you an amazing finish it forces the screen lower than you can ever get it yourself and the glue keeps it there. I have not had a problem removin the screen after either it's just a little harder.

Unplug the battery and hold the power button for 15 seconds then plug the battery back in and try to turn it on. But you replacing the home button wasn't a good idea because now the Touch ID functions will never work again

Are you using an anti static mat? I have never had that issue and I always use one and ground myself. It's also very possible the screens you are using are just going bad very quickly. I would try getting higher quality screens first because I would bet that's really the problem

Your LCD is slowly failing you will eventually notice the lines get worse and worse and then the touch screen will start to act funny. I would get the screen replaced ASAP to avoid having it get worse

It doesnt really matter because as soon as you get passed the sim screen you will be asked the iCloud account information for the find my iPhone. So you shouldn't waste your time.

Try and restore the phone, its very possible the touch ID got damaged but usually a restore helps

The mod might be taking too much power Update (06/15/2016): Make sure the cable is seated properly to the motherboard, then do a restore

Use an external CD drive from walmart or use disk utlity to make a bootable Usb