I work at an Apple repair centre in based in the UK and we have recently encountered MAJOR issues with replacement home buttons. It turns out that home buttons are linked too the logic board on each handset due to the method in which Apple stores you biometric data. Due to this, to the greatest extent of our knowledge, any update (through setting on the phone, updating on the phone, updating through iTunes or resting on iTunes) will cause an ERROR 53 to occur. As of yet we have not be able to rescue a handset from this state. If any body has any further knowledge it would be massively appreciated, as a community we need to get to the bottom of this before anybody had any major disasters.